Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes

Mutations in genomes of species are frequently distributed non-randomly, resulting in mutation clusters, including recently discovered kataegis in tumors. DNA editing deaminases play the prominent role in the etiology of these mutations. To gain insight into the enigmatic mechanisms of localized hyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Lada, Artem G., Kliver, Sergei F., Dhar, Alok, Polev, Dmitrii E., Masharsky, Alexey E., Rogozin, Igor B., Pavlov, Youri I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420506/
https://www.ncbi.nlm.nih.gov/pubmed/25941824
http://dx.doi.org/10.1371/journal.pgen.1005217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420506/
https://www.ncbi.nlm.nih.gov/pubmed/25941824
http://dx.doi.org/10.1371/journal.pgen.1005217

Ejemplares similares