Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides

The conjugation of oligonucleotides with reporters is of great interest for improving their intrinsic properties or endowing new ones. In this context, we report herein a new procedure for the bis-labelling of oligonucleotides through oxime ligation (Click-O) and copper(I)-catalyzed alkyne–azide cyc...

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Detalles Bibliográficos
Autores principales: Estalayo-Adriàn, Sandra, Lartia, Rémy, Meyer, Albert, Vasseur, Jean-Jacques, Morvan, François, Defrancq, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420589/
https://www.ncbi.nlm.nih.gov/pubmed/25969815
http://dx.doi.org/10.1002/open.201402099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420589/
https://www.ncbi.nlm.nih.gov/pubmed/25969815
http://dx.doi.org/10.1002/open.201402099

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