Site-Specific Radioiodination of HER2-Targeting Affibody Molecules using 4-Iodophenethylmaleimide Decreases Renal Uptake of Radioactivity

Affibody molecules are small scaffold-based affinity proteins with promising properties as probes for radionuclide-based molecular imaging. However, a high reabsorption of radiolabeled Affibody molecules in kidneys is an issue. We have shown that the use of (125)I-3-iodo-((4-hydroxyphenyl)ethyl)male...

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Detalles Bibliográficos
Autores principales: Strand, Joanna, Nordeman, Patrik, Honarvar, Hadis, Altai, Mohamed, Orlova, Anna, Larhed, Mats, Tolmachev, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420590/
https://www.ncbi.nlm.nih.gov/pubmed/25969816
http://dx.doi.org/10.1002/open.201402097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420590/
https://www.ncbi.nlm.nih.gov/pubmed/25969816
http://dx.doi.org/10.1002/open.201402097

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