Sustained Interleukin-1β Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids

Clinical treatment with glucocorticoids (GC) can be complicated by cytokine-induced glucocorticoid low-responsiveness (GC-resistance, GCR), a condition associated with a homogeneous reduction in the expression of GC-receptor- (GR-) driven anti-inflammatory genes. However, GR level and phosphorylatio...

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Detalles Bibliográficos
Autores principales: Escoll, Pedro, Ranz, Ismael, Muñoz-Antón, Norman, van-den-Rym, Ana, Alvarez-Mon, Melchor, Martínez-Alonso, Carlos, Sanz, Eva, de-la-Hera, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421076/
https://www.ncbi.nlm.nih.gov/pubmed/25977599
http://dx.doi.org/10.1155/2015/347965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421076/
https://www.ncbi.nlm.nih.gov/pubmed/25977599
http://dx.doi.org/10.1155/2015/347965

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