A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

Protein aggregation plays a key role in neurodegenerative disease, giving rise to small oligomers that may become cytotoxic to cells. The fundamental microscopic reactions taking place during aggregation, and their rate constants, have been difficult to determine due to lack of suitable methods to i...

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Detalles Bibliográficos
Autores principales: Shammas, Sarah L., Garcia, Gonzalo A., Kumar, Satish, Kjaergaard, Magnus, Horrocks, Mathew H., Shivji, Nadia, Mandelkow, Eva, Knowles, Tuomas P.J., Mandelkow, Eckhard, Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421837/
https://www.ncbi.nlm.nih.gov/pubmed/25926130
http://dx.doi.org/10.1038/ncomms8025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421837/
https://www.ncbi.nlm.nih.gov/pubmed/25926130
http://dx.doi.org/10.1038/ncomms8025

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