Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

Fluoroquinolones are one of the most commonly prescribed classes of antibiotics, but fluoroquinolone resistance (FQR) is widespread and increasing. Deoxynybomycin (DNM) is a natural-product antibiotic with an unusual mechanism of action, inhibiting the mutant DNA gyrase that confers FQR. Unfortunate...

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Detalles Bibliográficos
Autores principales: Parkinson, Elizabeth I., Bair, Joseph S., Nakamura, Bradley A., Lee, Hyang Y., Kuttab, Hani I., Southgate, Emma H., Lezmi, Stéphane, Lau, Gee W., Hergenrother, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421842/
https://www.ncbi.nlm.nih.gov/pubmed/25907309
http://dx.doi.org/10.1038/ncomms7947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421842/
https://www.ncbi.nlm.nih.gov/pubmed/25907309
http://dx.doi.org/10.1038/ncomms7947

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