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A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation

The fundamental question of which genes are most important in controlling liver regeneration remains unanswered. We employed a parallel screen to test the impact of 43 selected genes on liver repopulation in the Fah(−/−) mouse model of hereditary tyrosinemia. We discovered that the transcription fac...

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Detalles Bibliográficos
Autores principales: Wangensteen, Kirk J., Zhang, Sophia, Greenbaum, Linda E., Kaestner, Klaus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421979/
https://www.ncbi.nlm.nih.gov/pubmed/25934503
http://dx.doi.org/10.1101/gad.258855.115