Cargando…
A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation
The fundamental question of which genes are most important in controlling liver regeneration remains unanswered. We employed a parallel screen to test the impact of 43 selected genes on liver repopulation in the Fah(−/−) mouse model of hereditary tyrosinemia. We discovered that the transcription fac...
Autores principales: | Wangensteen, Kirk J., Zhang, Sophia, Greenbaum, Linda E., Kaestner, Klaus H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421979/ https://www.ncbi.nlm.nih.gov/pubmed/25934503 http://dx.doi.org/10.1101/gad.258855.115 |
Ejemplares similares
-
Genome-Wide Location Analysis Reveals Distinct Transcriptional Circuitry by Paralogous Regulators Foxa1 and Foxa2
por: Bochkis, Irina M., et al.
Publicado: (2012) -
Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice
por: Wang, Min-Jun, et al.
Publicado: (2018) -
Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site
por: Tuteja, Geetu, et al.
Publicado: (2008) -
FoxA factors: the chromatin key and doorstop essential for liver development and function
por: Heslop, James A., et al.
Publicado: (2020) -
Non-viral FoxM1 gene delivery to hepatocytes enhances liver repopulation
por: Xiang, D, et al.
Publicado: (2014)