Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protec...

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Detalles Bibliográficos
Autores principales: Rasmussen, Kasper D., Jia, Guangshuai, Johansen, Jens V., Pedersen, Marianne T., Rapin, Nicolas, Bagger, Frederik O., Porse, Bo T., Bernard, Olivier A., Christensen, Jesper, Helin, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421980/
https://www.ncbi.nlm.nih.gov/pubmed/25886910
http://dx.doi.org/10.1101/gad.260174.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421980/
https://www.ncbi.nlm.nih.gov/pubmed/25886910
http://dx.doi.org/10.1101/gad.260174.115

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