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Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
Ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) drives cell growth and underlies nucleolar structure and function, indirectly coordinating many fundamental cellular processes. The importance of keeping rDNA transcription under tight control is reflected by the fact that de...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422213/ https://www.ncbi.nlm.nih.gov/pubmed/25949792 http://dx.doi.org/10.1186/2045-3701-4-43 |