An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro molecular scale to the induction of mutant-like oligomerization in a wild-type protein. Using the common pathogenic E342K (Z) var...

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Detalles Bibliográficos
Autores principales: Irving, James A., Miranda, Elena, Haq, Imran, Perez, Juan, Kotov, Vadim R., Faull, Sarah V., Motamedi-Shad, Neda, Lomas, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422257/
https://www.ncbi.nlm.nih.gov/pubmed/25738741
http://dx.doi.org/10.1042/BJ20141569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422257/
https://www.ncbi.nlm.nih.gov/pubmed/25738741
http://dx.doi.org/10.1042/BJ20141569

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