Structure–activity exploration of a small-molecule Lipid II inhibitor

We have recently identified low-molecular weight compounds that act as inhibitors of Lipid II, an essential precursor of bacterial cell wall biosynthesis. Lipid II comprises specialized lipid (bactoprenol) linked to a hydrophilic head group consisting of a peptidoglycan subunit (N-acetyl glucosamine...

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Detalles Bibliográficos
Autores principales: Fletcher, Steven, Yu, Wenbo, Huang, Jing, Kwasny, Steven M, Chauhan, Jay, Opperman, Timothy J, MacKerell, Alexander D, de Leeuw, Erik PH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422293/
https://www.ncbi.nlm.nih.gov/pubmed/25987836
http://dx.doi.org/10.2147/DDDT.S79504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422293/
https://www.ncbi.nlm.nih.gov/pubmed/25987836
http://dx.doi.org/10.2147/DDDT.S79504

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