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Keap1 expression has independent prognostic value in pancreatic adenocarcinomas

BACKGROUND: Oxidative stress and redox-regulating enzymes may potentially accelerate pancreatic carcinogenesis and also affect chemoresistance. Recently major antioxidant response regulator NF-E2-related factor 2 (Nrf2) has been linked to poor prognosis in pancreatic cancer. Nrf2 activity is strictl...

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Detalles Bibliográficos
Autores principales: Isohookana, Joel, Haapasaari, Kirsi-Maria, Soini, Ylermi, Karihtala, Peeter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422296/
https://www.ncbi.nlm.nih.gov/pubmed/25879528
http://dx.doi.org/10.1186/s13000-015-0258-4