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Chk1 activity is required for BAK multimerization in association with PUMA during mitochondrial apoptosis
BACKGROUND: The Bcl-2 protein BAK is a key player in mitochondrial apoptosis and responds to a myriad of different death signals. Activation of BAK is a multistep process that involves a number of conformational changes mediated by BH3-only proteins or p53 which leads to BAK multimerization and pore...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422300/ https://www.ncbi.nlm.nih.gov/pubmed/25012639 http://dx.doi.org/10.1186/s12964-014-0042-1 |