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Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy
KRAS is the most commonly mutated oncogene in human cancers and is associated with poor prognosis and drug resistance. Let-7 is a family of tumor suppressor microRNAs that are frequently suppressed in solid tumors, where KRAS mutations are highly prevalent. In this study, we investigated the potenti...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422443/ https://www.ncbi.nlm.nih.gov/pubmed/25946136 http://dx.doi.org/10.1371/journal.pone.0126653 |