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Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy

KRAS is the most commonly mutated oncogene in human cancers and is associated with poor prognosis and drug resistance. Let-7 is a family of tumor suppressor microRNAs that are frequently suppressed in solid tumors, where KRAS mutations are highly prevalent. In this study, we investigated the potenti...

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Detalles Bibliográficos
Autores principales: Dai, Xin, Jiang, Ying, Tan, Chalet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422443/
https://www.ncbi.nlm.nih.gov/pubmed/25946136
http://dx.doi.org/10.1371/journal.pone.0126653

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