PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

Intestinal homeostasis requires precise control of intestinal stem cell (ISC) proliferation. In Drosophila, this control declines with age largely due to chronic activation of stress signaling and associated chronic inflammatory conditions. An important contributor to this condition is the age-assoc...

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Detalles Bibliográficos
Autores principales: Wang, Lifen, Ryoo, Hyung Don, Qi, Yanyan, Jasper, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422665/
https://www.ncbi.nlm.nih.gov/pubmed/25945494
http://dx.doi.org/10.1371/journal.pgen.1005220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422665/
https://www.ncbi.nlm.nih.gov/pubmed/25945494
http://dx.doi.org/10.1371/journal.pgen.1005220

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