An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

The epidermal growth factor receptor (EGFR) is overexpressed in approximately 90% of head and neck squamous cell carcinomas (HNSCC), and molecularly targeted therapy against the EGFR with the monoclonal antibody cetuximab modestly increases overall survival in head and neck cancer patients. We hypot...

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Detalles Bibliográficos
Autores principales: Kleczko, Emily K., Kim, Jihye, Keysar, Stephen B., Heasley, Lydia R., Eagles, Justin R., Simon, Matthew, Marshall, Marianne E., Singleton, Katherine R., Jimeno, Antonio, Tan, Aik-Choon, Heasley, Lynn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422719/
https://www.ncbi.nlm.nih.gov/pubmed/25946135
http://dx.doi.org/10.1371/journal.pone.0123600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422719/
https://www.ncbi.nlm.nih.gov/pubmed/25946135
http://dx.doi.org/10.1371/journal.pone.0123600

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