Characterization of a Novel Mouse Model of Alzheimer’s Disease—Amyloid Pathology and Unique β-Amyloid Oligomer Profile

Amyloid plaques composed of β-amyloid (Aβ) protein are a pathological hallmark of Alzheimer’s disease. We here report the generation and characterization of a novel transgenic mouse model of Aβ toxicity. The rTg9191 mice harbor a transgene encoding the 695 amino-acid isoform of human amyloid precurs...

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Detalles Bibliográficos
Autores principales: Liu, Peng, Paulson, Jennifer B., Forster, Colleen L., Shapiro, Samantha L., Ashe, Karen H., Zahs, Kathleen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422728/
https://www.ncbi.nlm.nih.gov/pubmed/25946042
http://dx.doi.org/10.1371/journal.pone.0126317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422728/
https://www.ncbi.nlm.nih.gov/pubmed/25946042
http://dx.doi.org/10.1371/journal.pone.0126317

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