Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

PURPOSE: A semi-mechanistic multiple-analyte population pharmacokinetics (PK) model was developed to describe the complex relationship between the different analytes of monomethyl auristatin E (MMAE) containing antibody-drug conjugates (ADCs) and to provide insight regarding the major pathways of co...

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Detalles Bibliográficos
Autores principales: Lu, Dan, Jin, Jin Yan, Girish, Sandhya, Agarwal, Priya, Li, Dongwei, Prabhu, Saileta, Dere, Randall C., Saad, Ola M., Nazzal, Denise, Koppada, Neelima, Ramanujan, Saroja, Ng, Chee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422865/
https://www.ncbi.nlm.nih.gov/pubmed/25467958
http://dx.doi.org/10.1007/s11095-014-1585-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422865/
https://www.ncbi.nlm.nih.gov/pubmed/25467958
http://dx.doi.org/10.1007/s11095-014-1585-y

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