Cargando…

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

PURPOSE: MITOsym, a new mathematical model of hepatocellular respiration and bioenergetics, has been developed in partnership with the DILIsym® model with the purpose of translating in vitro compound screening data into predictions of drug induced liver injury (DILI) risk for patients. The combined...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Y., Nadanaciva, S., Will, Y., Woodhead, J. L., Howell, B. A., Watkins, P. B., Siler, S. Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422870/ https://www.ncbi.nlm.nih.gov/pubmed/25504454 http://dx.doi.org/10.1007/s11095-014-1591-0

Ejemplares similares

A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial
por: Howell, B A, et al.
Publicado: (2014)

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury
por: Woodhead, Jeffrey L., et al.
Publicado: (2014)

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid–Mediated DILI
por: Woodhead, J L, et al.
Publicado: (2014)

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition
por: Beaudoin, James J., et al.
Publicado: (2023)

Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym(®), a Mechanistic Model of Drug‐Induced Liver Injury
por: Longo, DM, et al.
Publicado: (2016)

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
por: Woodhead, Jeffrey L., et al.
Publicado: (2019)

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses
por: Shoda, Lisl KM, et al.
Publicado: (2017)

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling
por: Woodhead, Jeffrey L, et al.
Publicado: (2022)

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury
por: Longo, Diane M, et al.
Publicado: (2019)

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors
por: Woodhead, Jeffrey L., et al.
Publicado: (2017)

Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters
por: Yang, K, et al.
Publicado: (2017)

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
por: Holmström, Kira M., et al.
Publicado: (2013)

Toward mechanistic modeling and rational engineering of plant respiration
por: Wendering, Philipp, et al.
Publicado: (2023)

Computational Modeling of Substrate-Dependent Mitochondrial Respiration and Bioenergetics in the Heart and Kidney Cortex and Outer Medulla
por: Sadri, Shima, et al.
Publicado: (2023)

Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity
por: Generaux, Grant, et al.
Publicado: (2019)

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches
por: Bhattacharya, Sudin, et al.
Publicado: (2012)

Mechanistic Investigations Support Liver Safety of Ubrogepant
por: Smith, Brenda, et al.
Publicado: (2020)

Mechanistic mathematical model of polarity in yeast
por: Savage, Natasha S., et al.
Publicado: (2012)

Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials
por: Longo, DM, et al.
Publicado: (2017)

CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells
por: Aye, Cho-Cho, et al.
Publicado: (2023)

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling
por: Woodhead, Jeffrey L., et al.
Publicado: (2018)

Bioenergetic Phenotyping of DEN-Induced Hepatocellular Carcinoma Reveals a Link Between Adenylate Kinase Isoform Expression and Reduced Complex I-Supported Respiration
por: McLaughlin, Kelsey L., et al.
Publicado: (2022)

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity
por: Yang, Kyunghee, et al.
Publicado: (2014)

Development of a prognostic model for hepatocellular carcinoma using genes involved in aerobic respiration
por: Rao, Jiawei, et al.
Publicado: (2021)

Mechanistic mathematical models: An underused platform for HPV research
por: Ryser, Marc D., et al.
Publicado: (2017)

Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling
por: Woodhead, J. L., et al.
Publicado: (2020)

Evolutionary primacy of sodium bioenergetics
por: Mulkidjanian, Armen Y, et al.
Publicado: (2008)

Effect of oxygen tension on bioenergetics and proteostasis in young and old myoblast precursor cells()
por: Konigsberg, M., et al.
Publicado: (2013)

Deciphering signal transduction networks in the liver by mechanistic mathematical modelling
por: D’Alessandro, Lorenza A., et al.
Publicado: (2022)

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
por: Battista, Christina, et al.
Publicado: (2018)

Bioenergetics /
por: Lowen, Alexander
Publicado: (1975)

A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
por: Alam, Md Maksudul, et al.
Publicado: (2016)

Mechanistic Mathematical Modeling Tests Hypotheses of the Neurovascular Coupling in fMRI
por: Lundengård, Karin, et al.
Publicado: (2016)

Building a mechanistic mathematical model of hepatitis C virus entry
por: Kalemera, Mphatso, et al.
Publicado: (2019)

Mitochondrially targeted compounds and their impact on cellular bioenergetics()
por: Reily, Colin, et al.
Publicado: (2013)

Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas
por: Lin, Wey-Ran, et al.
Publicado: (2019)

Correction to: A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
por: Alam, Md Maksudul, et al.
Publicado: (2018)

Mechanisms in Bioenergetics
por: Taborsky, George
Publicado: (1966)

Principles of Bioenergetics
por: Skulachev, Vladimir P, et al.
Publicado: (2013)

Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy
por: Lim, Tony K. Y., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_biljkv8lit8jcvff5b444k8i8m