LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways

5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1 monocytes with LPS (0~3 µg/ml) increased 5-LO promoter activity and 5-LO protein...

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Detalles Bibliográficos
Autores principales: Lee, Seung Jin, Seo, Kyo Won, Kim, Chi Dae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422967/
https://www.ncbi.nlm.nih.gov/pubmed/25954132
http://dx.doi.org/10.4196/kjpp.2015.19.3.263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422967/
https://www.ncbi.nlm.nih.gov/pubmed/25954132
http://dx.doi.org/10.4196/kjpp.2015.19.3.263

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