Cargando…

LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways

5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1 monocytes with LPS (0~3 µg/ml) increased 5-LO promoter activity and 5-LO protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seung Jin, Seo, Kyo Won, Kim, Chi Dae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Physiological Society and The Korean Society of Pharmacology 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422967/ https://www.ncbi.nlm.nih.gov/pubmed/25954132 http://dx.doi.org/10.4196/kjpp.2015.19.3.263

Ejemplares similares

Crosstalk between Akt and NF‐κB pathway mediates inhibitory effect of gas6 on monocytes‐endothelial cells interactions stimulated by P. gingivalis‐LPS
por: Wang, Xuekui, et al.
Publicado: (2020)

NF-κB inhibition attenuates LPS-induced TLR4 activation in monocyte cells
por: Wan, Jian, et al.
Publicado: (2016)

Benzyl Isothiocyanate Attenuates Inflammasome Activation in Pseudomonas aeruginosa LPS-Stimulated THP-1 Cells and Exerts Regulation through the MAPKs/NF-κB Pathway
por: Park, Won Sun, et al.
Publicado: (2022)

Mechanical Stretch Increases MMP-2 Production in Vascular Smooth Muscle Cells via Activation of PDGFR-β/Akt Signaling Pathway
por: Seo, Kyo Won, et al.
Publicado: (2013)

Stachydrine prevents LPS‐induced bone loss by inhibiting osteoclastogenesis via NF‐κB and Akt signalling
por: Meng, Jiahong, et al.
Publicado: (2019)

Aspirin inhibits LPS-induced macrophage activation via the NF-κB pathway
por: Liu, Yitong, et al.
Publicado: (2017)

Anti-Inflammatory Potential of Carpomitra costata Ethanolic Extracts via Inhibition of NF-κB and AP-1 Activation in LPS-Stimulated RAW264.7 Macrophages
por: Yim, Mi-Jin, et al.
Publicado: (2018)

Anti-Inflammatory Effects of Aster incisus through the Inhibition of NF-κB, MAPK, and Akt Pathways in LPS-Stimulated RAW 264.7 Macrophages
por: Ngabire, Daniel, et al.
Publicado: (2018)

LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding
por: Lee, Hwan Hee, et al.
Publicado: (2016)

Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways
por: Shen, Bingyu, et al.
Publicado: (2023)

Norcantharidin Facilitates LPS-Mediated Immune Responses by Up-Regulation of AKT/NF-κB Signaling in Macrophages
por: Zhao, Qufei, et al.
Publicado: (2012)

Continuous Activation of Dopamine Receptors Alleviates LPS-Induced Liver Injury in Mice via β-arrestin2 Dependent Akt/NF-κB Pathway
por: Li, Mingan, et al.
Publicado: (2022)

TLR4-Mediated Expression of Mac-1 in Monocytes Plays a Pivotal Role in Monocyte Adhesion to Vascular Endothelium
por: Lee, Seung Jin, et al.
Publicado: (2014)

VSTM1 regulates monocyte/macrophage function via the NF-κB signaling pathway
por: Wang, Xiao-Fei, et al.
Publicado: (2021)

Phenethylferulate as a natural inhibitor of inflammation in LPS-stimulated RAW 264.7 macrophages: focus on NF-κB, Akt and MAPK signaling pathways
por: Yan, Zhongjie, et al.
Publicado: (2023)

METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway
por: Wang, Jinghua, et al.
Publicado: (2019)

Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-κB Pathway
por: Kim, Eun Jeong, et al.
Publicado: (2015)

Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling
por: Ito, Fumitake, et al.
Publicado: (2019)

Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT/NF-κB p65, ERK1/2 and P38 Signaling Pathway
por: Li, Yanwei, et al.
Publicado: (2018)

Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
por: Zhao, Dong, et al.
Publicado: (2019)

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway
por: Badshah, Haroon, et al.
Publicado: (2016)

Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways
por: Lee, Nami, et al.
Publicado: (2021)

Transcriptional profiling of the LPS induced NF-κB response in macrophages
por: Sharif, Omar, et al.
Publicado: (2007)

Metformin attenuates LPS-induced neuronal injury and cognitive impairments by blocking NF-κB pathway
por: Zhou, Chenliang, et al.
Publicado: (2021)

Irisin protects female mice with LPS-induced endometritis through the AMPK/NF-κB pathway
por: Jiang, Xi, et al.
Publicado: (2021)

Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways
por: Tanaka, Miori, et al.
Publicado: (2018)

Ginsenoside Rb3 Inhibits Pro-Inflammatory Cytokines via MAPK/AKT/NF-κB Pathways and Attenuates Rat Alveolar Bone Resorption in Response to Porphyromonas gingivalis LPS
por: Sun, Minmin, et al.
Publicado: (2020)

Gualou Guizhi Granule Suppresses LPS-Induced Inflammatory Response of Microglia and Protects against Microglia-Mediated Neurotoxicity in HT-22 via Akt/NF-κB Signaling Pathways
por: Chang, Xiaona, et al.
Publicado: (2021)

Hepatoprotective effect of syringin combined with costunolide against LPS-induced acute liver injury in L-02 cells via Rac1/AKT/NF-κB signaling pathway
por: Mao, Jingxin, et al.
Publicado: (2023)

Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt
por: Nie, Yunjuan, et al.
Publicado: (2019)

Oroxylin-A Rescues LPS-Induced Acute Lung Injury via Regulation of NF-κB Signaling Pathway in Rodents
por: Tseng, Tzu-Ling, et al.
Publicado: (2012)

Cortisol modulates inflammatory responses in LPS-stimulated RAW264.7 cells via the NF-κB and MAPK pathways
por: Dong, Junsheng, et al.
Publicado: (2018)

Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway
por: Xiang, Nan-lin, et al.
Publicado: (2016)

The Role of Autophagy in Kidney Inflammatory Injury via the NF-κB Route Induced by LPS
por: Wu, Yu, et al.
Publicado: (2015)

Artemisinin inhibits monocyte adhesion to HUVECs through the NF-κB and MAPK pathways in vitro
por: WANG, YUE, et al.
Publicado: (2016)

Resveratrol affects the migration and apoptosis of monocytes by blocking HMGB1/NF-κB pathway
por: Zhang, Yuwei, et al.
Publicado: (2021)

Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-κB signaling pathway
por: Shi, Jiangying, et al.
Publicado: (2017)

Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats
por: Khan, Muhammad Sohail, et al.
Publicado: (2019)

Correspondence on Letter regarding “Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF-κB signaling pathways”
por: Lee, Seung Min, et al.
Publicado: (2023)

Dynamic Motile T Cells Highly Respond to the T Cell Stimulation via PI3K-Akt and NF-κB Pathways
por: Kim, Hye-Ran, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9n2dnhmvtkrdnorf4f6mh2hu10