KRAS and BRAF Mutation Detection: Is Immunohistochemistry a Possible Alternative to Molecular Biology in Colorectal Cancer?

KRAS genotyping is mandatory in metastatic colorectal cancer treatment prior to undertaking antiepidermal growth factor receptor (EGFR) monoclonal antibody therapy. BRAF V600E mutation is often present in colorectal carcinoma with CpG island methylator phenotype and microsatellite instability. Curre...

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Detalles Bibliográficos
Autores principales: Piton, Nicolas, Borrini, Francesco, Bolognese, Antonio, Lamy, Aude, Sabourin, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422999/
https://www.ncbi.nlm.nih.gov/pubmed/25983749
http://dx.doi.org/10.1155/2015/753903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422999/
https://www.ncbi.nlm.nih.gov/pubmed/25983749
http://dx.doi.org/10.1155/2015/753903

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