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Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP
Cyclic dinucleotides act as intracellular second messengers, modulating a variety of cellular activities including innate immune activation. Although phosphodiesterases (PDEs) hydrolyzing c-di-GMP and c-di-AMP have been identified, no PDEs for cGAMPs have been reported. Here we identified the first...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423081/ https://www.ncbi.nlm.nih.gov/pubmed/25837739 http://dx.doi.org/10.1038/cr.2015.40 |