Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

BACKGROUND: 5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats as the experimental model. METHODS: RT with 2 Gy was delivered to the whole pelv...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsieh, Chen-Hsi, Hou, Mei-Ling, Wang, Li-Ying, Tai, Hung-Chi, Tsai, Tung-Hu, Chen, Yu-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423102/
https://www.ncbi.nlm.nih.gov/pubmed/25928348
http://dx.doi.org/10.1186/s12885-015-1344-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423102/
https://www.ncbi.nlm.nih.gov/pubmed/25928348
http://dx.doi.org/10.1186/s12885-015-1344-4

Ejemplares similares