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Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

BACKGROUND: 5-fluorouracil (5-FU) is employed to enhance radiotherapy (RT) effect. Here, we evaluated the influence of whole-pelvic irradiation on the pharmacokinetics (PK) of 5-FU in plasma and lymphatic system of rats as the experimental model. METHODS: RT with 2 Gy was delivered to the whole pelv...

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Detalles Bibliográficos
Autores principales:	Hsieh, Chen-Hsi, Hou, Mei-Ling, Wang, Li-Ying, Tai, Hung-Chi, Tsai, Tung-Hu, Chen, Yu-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423102/ https://www.ncbi.nlm.nih.gov/pubmed/25928348 http://dx.doi.org/10.1186/s12885-015-1344-4

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