A study on quantitative structure–activity relationship and molecular docking of metalloproteinase inhibitors based on L-tyrosine scaffold

BACKGROUND: MMP-2 enzyme is a kind of matrix metalloproteinases that digests the denatured collagens and gelatins. It is highly involved in the process of tumor invasion and has been considered as a promising target for cancer therapy. The structural requirements of an MMP-2 inhibitor are: (1) a fun...

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Detalles Bibliográficos
Autores principales: Abbasi, Maryam, Ramezani, Fatemeh, Elyasi, Maryam, Sadeghi-Aliabadi, Hojjat, Amanlou, Massoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423142/
https://www.ncbi.nlm.nih.gov/pubmed/25925871
http://dx.doi.org/10.1186/s40199-015-0111-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423142/
https://www.ncbi.nlm.nih.gov/pubmed/25925871
http://dx.doi.org/10.1186/s40199-015-0111-z

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