Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers

The accumulation of amyloid-β protein (Aβ) is an early event associated with synaptic and mitochondrial damage in Alzheimer's disease (AD). Recent studies have implicated the filamentous actin (F-actin) severing protein, Cofilin, in synaptic remodeling, mitochondrial dysfunction, and AD pathoge...

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Detalles Bibliográficos
Autores principales: Woo, J A, Zhao, X, Khan, H, Penn, C, Wang, X, Joly-Amado, A, Weeber, E, Morgan, D, Kang, D E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423195/
https://www.ncbi.nlm.nih.gov/pubmed/25698445
http://dx.doi.org/10.1038/cdd.2015.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423195/
https://www.ncbi.nlm.nih.gov/pubmed/25698445
http://dx.doi.org/10.1038/cdd.2015.5

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