Cargando…

Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers

The accumulation of amyloid-β protein (Aβ) is an early event associated with synaptic and mitochondrial damage in Alzheimer's disease (AD). Recent studies have implicated the filamentous actin (F-actin) severing protein, Cofilin, in synaptic remodeling, mitochondrial dysfunction, and AD pathoge...

Descripción completa

Detalles Bibliográficos
Autores principales:	Woo, J A, Zhao, X, Khan, H, Penn, C, Wang, X, Joly-Amado, A, Weeber, E, Morgan, D, Kang, D E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423195/ https://www.ncbi.nlm.nih.gov/pubmed/25698445 http://dx.doi.org/10.1038/cdd.2015.5

Ejemplares similares

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia
por: Nagata-Ohashi, Kyoko, et al.
Publicado: (2004)

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction
por: Woo, J A, et al.
Publicado: (2015)

GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis
por: Xu, Xuehua, et al.
Publicado: (2015)

Slingshot-1L, a cofilin phosphatase, induces primary breast cancer metastasis
por: Chen, Chen, et al.
Publicado: (2017)

Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration
por: Nishita, Michiru, et al.
Publicado: (2005)

The Cofilin Phosphatase Slingshot Homolog 1 (SSH1) Links NOD1 Signaling to Actin Remodeling
por: Bielig, Harald, et al.
Publicado: (2014)

Slingshot to the lamellipod
por: LeBrasseur, Nicole
Publicado: (2004)

Protein Kinase D1 regulates Cofilin mediated F-actin reorganization and cell motility via Slingshot
por: Eiseler, Tim, et al.
Publicado: (2009)

Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes
por: Iwase, Shohei, et al.
Publicado: (2013)

BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin
por: Wen, Zhexing, et al.
Publicado: (2007)

Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α(4)β(7) integrin antibody
por: He, Sijia, et al.
Publicado: (2019)

Bacteria slingshot more on soft surfaces
por: Zhang, Rongrong, et al.
Publicado: (2014)

Filming enhanced ionization in an ultrafast triatomic slingshot
por: Howard, Andrew J., et al.
Publicado: (2023)

Requirements-led project management: discovering David's Slingshot
por: Robertson, Suzanne, et al.
Publicado: (2005)

The Boring Billion, a slingshot for Complex Life on Earth
por: Mukherjee, Indrani, et al.
Publicado: (2018)

Resveratrol Preconditioning Protects Against Ischemia-Induced Synaptic Dysfunction and Cofilin Hyperactivation in the Mouse Hippocampal Slice
por: Escobar, Iris, et al.
Publicado: (2023)

The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer’s Disease
por: Ben Zablah, Youssif, et al.
Publicado: (2020)

Cofilin-induced cooperative conformational changes of actin subunits revealed using cofilin-actin fusion protein
por: Umeki, Nobuhisa, et al.
Publicado: (2016)

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
por: Street, Kelly, et al.
Publicado: (2018)

The behavior of osteoblast-like cells on various substrates with functional blocking of integrin-β1 and integrin-β3
por: Siebers, M. C., et al.
Publicado: (2007)

Alzheimer's disease: synaptic dysfunction and Aβ
por: Shankar, Ganesh M, et al.
Publicado: (2009)

Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss
por: Zhao, Chunhui, et al.
Publicado: (2019)

Integrin α4β7 switches its ligand specificity via distinct conformer-specific activation
por: Wang, ShiHui, et al.
Publicado: (2018)

Integrins control motile strategy through a Rho–cofilin pathway
por: Danen, Erik H.J., et al.
Publicado: (2005)

The importance of N-glycosylation on β(3) integrin ligand binding and conformational regulation
por: Cai, Xiulei, et al.
Publicado: (2017)

Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis
por: Lin, Chiao-Ming, et al.
Publicado: (2012)

Slingshot feeding of the goblin shark Mitsukurina owstoni (Pisces: Lamniformes: Mitsukurinidae)
por: Nakaya, Kazuhiro, et al.
Publicado: (2016)

The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice
por: Xu, Ke, et al.
Publicado: (2023)

Role of Aβ in Alzheimer’s-related synaptic dysfunction
por: Zhang, Huiqin, et al.
Publicado: (2022)

M2 Macrophages Mediate the Resistance of Gastric Adenocarcinoma Cells to 5-Fluorouracil through the Expression of Integrin β3, Focal Adhesion Kinase, and Cofilin
por: Ngabire, Daniel, et al.
Publicado: (2020)

Regulation of α5β1 integrin conformation and function by urokinase receptor binding
por: Wei, Ying, et al.
Publicado: (2005)

Fingerprints of slingshot non-sequential double ionization on two-electron probability distributions
por: Katsoulis, G. P., et al.
Publicado: (2019)

Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT
por: Rabie, Emann M., et al.
Publicado: (2021)

Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change
por: Su, Yang, et al.
Publicado: (2022)

Differential expressions of integrin-linked kinase, β-parvin and cofilin 1 in high-fat diet induced prostate cancer progression in a transgenic mouse model
por: Hu, Meng-Bo, et al.
Publicado: (2018)

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease
por: Tu, Shichun, et al.
Publicado: (2014)

Slingshot: a PiggyBac based transposon system for tamoxifen-inducible ‘self-inactivating’ insertional mutagenesis
por: Kong, Jun, et al.
Publicado: (2010)

β-Turn Mimics by Chemical Ligation
por: Crecente-Garcia, Selma, et al.
Publicado: (2020)

Toward Understanding the Conformational Dynamics of RNA Ligation
por: Swift, Robert V., et al.
Publicado: (2009)

No substitute for β3 integrin
por: Leslie, Mitch
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_9nddrg2uc286l8m5spg8cf0ebb