Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization

Dishevelled relays Wnt signals from the plasma membrane to different cytoplasmic effectors. Its signalling activity depends on its DIX domain, which undergoes head-to-tail polymerization to assemble signalosomes. The DIX domain is ubiquitinated in vivo at multiple lysines, which can be antagonized b...

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Detalles Bibliográficos
Autores principales: Madrzak, Julia, Fiedler, Marc, Johnson, Christopher M., Ewan, Richard, Knebel, Axel, Bienz, Mariann, Chin, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423210/
https://www.ncbi.nlm.nih.gov/pubmed/25907794
http://dx.doi.org/10.1038/ncomms7718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423210/
https://www.ncbi.nlm.nih.gov/pubmed/25907794
http://dx.doi.org/10.1038/ncomms7718

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