The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest

Cell death on extended mitotic arrest is considered arguably most critical for the efficacy of microtubule-targeting agents (MTAs) in anticancer therapy. While the molecular machinery controlling mitotic arrest on MTA treatment, the spindle assembly checkpoint (SAC), appears well defined, the molecu...

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Detalles Bibliográficos
Autores principales: Haschka, Manuel D., Soratroi, Claudia, Kirschnek, Susanne, Häcker, Georg, Hilbe, Richard, Geley, Stephan, Villunger, Andreas, Fava, Luca L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423218/
https://www.ncbi.nlm.nih.gov/pubmed/25922916
http://dx.doi.org/10.1038/ncomms7891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423218/
https://www.ncbi.nlm.nih.gov/pubmed/25922916
http://dx.doi.org/10.1038/ncomms7891

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