Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

L-Oligonucleotide aptamers (Spiegelmers) consist of non-natural L-configured nucleotides and are of particular therapeutic interest due to their high resistance to plasma nucleases. The anaphylatoxin C5a, a potent inflammatory mediator generated during complement activation that has been implicated...

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Detalles Bibliográficos
Autores principales: Yatime, Laure, Maasch, Christian, Hoehlig, Kai, Klussmann, Sven, Andersen, Gregers R., Vater, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423239/
https://www.ncbi.nlm.nih.gov/pubmed/25901944
http://dx.doi.org/10.1038/ncomms7481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423239/
https://www.ncbi.nlm.nih.gov/pubmed/25901944
http://dx.doi.org/10.1038/ncomms7481

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