Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis

Promoter silencing by ectopic de novo methylation of tumor suppressor genes has been proposed as comparable or equivalent to inactivating mutations as a factor in carcinogenesis. However, this hypotheses had not previously been tested by high resolution, high-coverage whole-genome methylation profil...

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Detalles Bibliográficos
Autores principales: O’Donnell, Anne H., Edwards, John R., Rollins, Robert A., Vander Kraats, Nathan D., Su, Tao, Hibshoosh, Hanina H., Bestor, Timothy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423420/
https://www.ncbi.nlm.nih.gov/pubmed/25960928
http://dx.doi.org/10.4236/jct.2014.514131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423420/
https://www.ncbi.nlm.nih.gov/pubmed/25960928
http://dx.doi.org/10.4236/jct.2014.514131

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