BET Bromodomains Regulate Transforming Growth Factor-β-induced Proliferation and Cytokine Release in Asthmatic Airway Smooth Muscle

Airway smooth muscle (ASM) mass is increased in asthma, and ASM cells from patients with asthma are hyperproliferative and release more IL-6 and CXCL8. The BET (bromo- and extra-terminal) family of proteins (Brd2, Brd3, and Brd4) govern the assembly of histone acetylation-dependent chromatin complex...

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Detalles Bibliográficos
Autores principales: Perry, Mark M., Durham, Andrew L., Austin, Philip J., Adcock, Ian M., Chung, Kian Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423696/
https://www.ncbi.nlm.nih.gov/pubmed/25697361
http://dx.doi.org/10.1074/jbc.M114.612671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423696/
https://www.ncbi.nlm.nih.gov/pubmed/25697361
http://dx.doi.org/10.1074/jbc.M114.612671

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