Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide

In the 1950s the drug thalidomide administered as a sedative to pregnant women led to the birth of thousands of children with multiple defects. Despite its teratogenicity, thalidomide and its derivatives lenalidomide and pomalidomide (together known as Immunomodulatory Drugs: IMiDs) recently emerged...

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Detalles Bibliográficos
Autores principales: Fischer, Eric S., Böhm, Kerstin, Lydeard, John R., Yang, Haidi, Stadler, Michael B., Cavadini, Simone, Nagel, Jane, Serluca, Fabrizio, Acker, Vincent, Lingaraju, Gondichatnahalli M., Tichkule, Ritesh B., Schebesta, Michael, Forrester, William C., Schirle, Markus, Hassiepen, Ulrich, Ottl, Johannes, Hild, Marc, Beckwith, Rohan E. J., Harper, J. Wade, Jenkins, Jeremy L., Thomä, Nicolas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423819/
https://www.ncbi.nlm.nih.gov/pubmed/25043012
http://dx.doi.org/10.1038/nature13527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423819/
https://www.ncbi.nlm.nih.gov/pubmed/25043012
http://dx.doi.org/10.1038/nature13527

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