Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature

Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs), have facilitated studies that contributed to our understanding of genetic influence on human traits. However, the degree to which cell lines faithfully maintain differences in donor-specific phenotypes is still debated. We h...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomas, Samantha M., Kagan, Courtney, Pavlovic, Bryan J., Burnett, Jonathan, Patterson, Kristen, Pritchard, Jonathan K., Gilad, Yoav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423863/
https://www.ncbi.nlm.nih.gov/pubmed/25950834
http://dx.doi.org/10.1371/journal.pgen.1005216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423863/
https://www.ncbi.nlm.nih.gov/pubmed/25950834
http://dx.doi.org/10.1371/journal.pgen.1005216

Ejemplares similares