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Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature
Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs), have facilitated studies that contributed to our understanding of genetic influence on human traits. However, the degree to which cell lines faithfully maintain differences in donor-specific phenotypes is still debated. We h...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423863/ https://www.ncbi.nlm.nih.gov/pubmed/25950834 http://dx.doi.org/10.1371/journal.pgen.1005216 |