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The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study

The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process. Indeed, we found that new dendritic spines in mice lacking CNTNAP2 were formed at normal rat...

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Detalles Bibliográficos
Autores principales: Gdalyahu, Amos, Lazaro, Maria, Penagarikano, Olga, Golshani, Peyman, Trachtenberg, Joshua T., Gescwind, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423902/
https://www.ncbi.nlm.nih.gov/pubmed/25951243
http://dx.doi.org/10.1371/journal.pone.0125633