ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways

In the normal human colon, aldehyde dehydrogenase 1B1 (ALDH1B1) is expressed only at the crypt base, along with stem cells. It is also highly expressed in the human colonic adenocarcinomas. This pattern of expression corresponds closely to that observed for Wnt/β-catenin signaling activity. The pres...

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Detalles Bibliográficos
Autores principales: Singh, Surendra, Arcaroli, John, Chen, Ying, Thompson, David C., Messersmith, Wells, Jimeno, Antonio, Vasiliou, Vasilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423958/
https://www.ncbi.nlm.nih.gov/pubmed/25950950
http://dx.doi.org/10.1371/journal.pone.0121648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423958/
https://www.ncbi.nlm.nih.gov/pubmed/25950950
http://dx.doi.org/10.1371/journal.pone.0121648

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