High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination

Breakdown of B cell tolerance is a cardinal feature of systemic lupus erythematosus (SLE). Increased numbers of autoreactive mature naïve B cells have been described in SLE patients and autoantibodies have been shown to arise from autoreactive and non-autoreactive precursors. How these defects, in t...

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Detalles Bibliográficos
Autores principales: Kaur, Kaval, Zheng, Nai-Ying, Smith, Kenneth, Huang, Min, Li, Lie, Pauli, Noel T., Henry Dunand, Carole J., Lee, Jane-Hwei, Morrissey, Michael, Wu, Yixuan, Joachims, Michelle L., Munroe, Melissa E., Lau, Denise, Qu, Xinyan, Krammer, Florian, Wrammert, Jens, Palese, Peter, Ahmed, Rafi, James, Judith A., Wilson, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423960/
https://www.ncbi.nlm.nih.gov/pubmed/25951191
http://dx.doi.org/10.1371/journal.pone.0125618

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