CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes

Transcription through early-elongation checkpoints requires phosphorylation of negative transcription elongation factors (NTEFs) by the cyclin-dependent kinase (CDK)9. Using CDK9 inhibitors and global run-on sequencing (GRO-seq), we have mapped CDK9 inhibitor-sensitive checkpoints genome-wide in hum...

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Detalles Bibliográficos
Autores principales: Laitem, Clélia, Zaborowska, Justyna, Isa, Nur F., Kufs, Johann, Dienstbier, Martin, Murphy, Shona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424039/
https://www.ncbi.nlm.nih.gov/pubmed/25849141
http://dx.doi.org/10.1038/nsmb.3000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424039/
https://www.ncbi.nlm.nih.gov/pubmed/25849141
http://dx.doi.org/10.1038/nsmb.3000

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