Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX

The hexameric AAA+ ring of Escherichia. coli ClpX, an ATP-dependent protein unfolding and translocation machine, functions with the ClpP peptidase to degrade target substrates. For efficient function, ClpX subunits must switch between nucleotide-loadable (L) and nucleotide-unloadable (U) conformatio...

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Detalles Bibliográficos
Autores principales: Stinson, Benjamin M., Baytshtok, Vladimir, Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424054/
https://www.ncbi.nlm.nih.gov/pubmed/25866879
http://dx.doi.org/10.1038/nsmb.3012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424054/
https://www.ncbi.nlm.nih.gov/pubmed/25866879
http://dx.doi.org/10.1038/nsmb.3012

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