In vitro stability of therapeutically relevant, internally truncated dystrophins

BACKGROUND: The X-linked recessive disease Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding the protein dystrophin. Despite its large size, dystrophin is a highly stable protein, demonstrating cooperative unfolding during thermal denaturation as monitored by circular dic...

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Detalles Bibliográficos
Autores principales: McCourt, Jackie L, Rhett, Katrina K, Jaeger, Michele A, Belanto, Joseph J, Talsness, Dana M, Ervasti, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424174/
https://www.ncbi.nlm.nih.gov/pubmed/25954502
http://dx.doi.org/10.1186/s13395-015-0040-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424174/
https://www.ncbi.nlm.nih.gov/pubmed/25954502
http://dx.doi.org/10.1186/s13395-015-0040-z

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