Mutagenesis of the Aquaporin 4 Extracellular Domains Defines Restricted Binding Patterns of Pathogenic Neuromyelitis Optica IgG

Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water channels in the central nervous system leading to immune-mediated injury. We have previously demonstrated that a high proportion of CSF plasma cells of NMO patients produce antibody to the extracellular domains of the...

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Detalles Bibliográficos
Autores principales: Owens, Gregory P., Ritchie, Alanna, Rossi, Andrea, Schaller, Kristin, Wemlinger, Scott, Schumann, Hannah, Shearer, Andrew, Verkman, Alan S., Bennett, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424347/
https://www.ncbi.nlm.nih.gov/pubmed/25792738
http://dx.doi.org/10.1074/jbc.M115.647149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424347/
https://www.ncbi.nlm.nih.gov/pubmed/25792738
http://dx.doi.org/10.1074/jbc.M115.647149

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