Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion

Expansion of polyglutamine stretches leads to the formation of polyglutamine-containing neuronal aggregates and neuronal death in nine diseases for which there currently are no treatments or cures. This is largely due to a lack in understanding of the mechanisms by which expanded polyglutamine regio...

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Detalles Bibliográficos
Autores principales: Scarff, Charlotte A., Almeida, Bruno, Fraga, Joana, Macedo-Ribeiro, Sandra, Radford, Sheena E., Ashcroft, Alison E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424396/
https://www.ncbi.nlm.nih.gov/pubmed/25700012
http://dx.doi.org/10.1074/mcp.M114.044610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424396/
https://www.ncbi.nlm.nih.gov/pubmed/25700012
http://dx.doi.org/10.1074/mcp.M114.044610

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