Preferable sites and orientations of transgene inserted in the adenovirus vector genome: The E3 site may be unfavorable for transgene position

The adenovirus vector (AdV) can carry two transgenes in its genome, the therapeutic gene and a reporter gene, for example. The E3 insertion site has often been used for the expression of the second transgene. A transgene can be inserted at six different sites/orientations: E1, E3 and E4 sites, and r...

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Detalles Bibliográficos
Autores principales: Suzuki, M, Kondo, S, Pei, Z, Maekawa, A, Saito, I, Kanegae, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424821/
https://www.ncbi.nlm.nih.gov/pubmed/25588742
http://dx.doi.org/10.1038/gt.2014.124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424821/
https://www.ncbi.nlm.nih.gov/pubmed/25588742
http://dx.doi.org/10.1038/gt.2014.124

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