Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel

During the long-term evolution of animal toxins acting on potassium channels, the acidic residues can orientate the toxin binding interfaces by adjusting the molecular polarity. Based on the evolutionary function of toxin acidic residues, de novo peptide drugs with distinct binding interfaces were d...

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Detalles Bibliográficos
Autores principales: Chen, Zongyun, Hu, Youtian, Hong, Jing, Hu, Jun, Yang, Weishan, Xiang, Fang, Yang, Fan, Xie, Zili, Cao, Zhijian, Li, Wenxin, Lin, Donghai, Wu, Yingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424837/
https://www.ncbi.nlm.nih.gov/pubmed/25955787
http://dx.doi.org/10.1038/srep09881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424837/
https://www.ncbi.nlm.nih.gov/pubmed/25955787
http://dx.doi.org/10.1038/srep09881

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