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Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation
We tested whether loss of eukaryotic elongation factor 2 kinase (eEF2K) activity in macrophages suppresses development of atherosclerosis by transplanting bone marrow from mice with mutant eEF2K into ldlr(−/−) mice. Sixteen weeks after high-fat diet feeding, mutant eEF2K hematopoietic chimeras had a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pulsus Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424975/ https://www.ncbi.nlm.nih.gov/pubmed/25475470 http://dx.doi.org/10.1016/j.cjca.2014.09.019 |
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author | Zhang, Peng Riazy, Maziar Gold, Matthew Tsai, Shu-Huei McNagny, Kelly Proud, Christopher Duronio, Vincent |
author_facet | Zhang, Peng Riazy, Maziar Gold, Matthew Tsai, Shu-Huei McNagny, Kelly Proud, Christopher Duronio, Vincent |
author_sort | Zhang, Peng |
collection | PubMed |
description | We tested whether loss of eukaryotic elongation factor 2 kinase (eEF2K) activity in macrophages suppresses development of atherosclerosis by transplanting bone marrow from mice with mutant eEF2K into ldlr(−/−) mice. Sixteen weeks after high-fat diet feeding, mutant eEF2K hematopoietic chimeras had a dramatically reduced level of atherosclerotic plaque formation. M1-skewed macrophages from eEF2K knock-in mice have less tumour necrosis factor-α release and a lesser ability to induce expression of endothelial cell markers, providing a potential explanation for the role of eEF2K. Because eEF2K activity in cells of the hematopoietic compartment contributes to atherosclerosis development, drugs inhibiting eEF2K might have a beneficial effect in treatment of atherosclerosis. |
format | Online Article Text |
id | pubmed-4424975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Pulsus Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44249752015-05-13 Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation Zhang, Peng Riazy, Maziar Gold, Matthew Tsai, Shu-Huei McNagny, Kelly Proud, Christopher Duronio, Vincent Can J Cardiol Brief Rapid Report We tested whether loss of eukaryotic elongation factor 2 kinase (eEF2K) activity in macrophages suppresses development of atherosclerosis by transplanting bone marrow from mice with mutant eEF2K into ldlr(−/−) mice. Sixteen weeks after high-fat diet feeding, mutant eEF2K hematopoietic chimeras had a dramatically reduced level of atherosclerotic plaque formation. M1-skewed macrophages from eEF2K knock-in mice have less tumour necrosis factor-α release and a lesser ability to induce expression of endothelial cell markers, providing a potential explanation for the role of eEF2K. Because eEF2K activity in cells of the hematopoietic compartment contributes to atherosclerosis development, drugs inhibiting eEF2K might have a beneficial effect in treatment of atherosclerosis. Pulsus Group 2014-12 /pmc/articles/PMC4424975/ /pubmed/25475470 http://dx.doi.org/10.1016/j.cjca.2014.09.019 Text en © 2014 The Authors. Canadian Cardiovascular Society. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Rapid Report Zhang, Peng Riazy, Maziar Gold, Matthew Tsai, Shu-Huei McNagny, Kelly Proud, Christopher Duronio, Vincent Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation |
title | Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation |
title_full | Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation |
title_fullStr | Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation |
title_full_unstemmed | Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation |
title_short | Impairing Eukaryotic Elongation Factor 2 Kinase Activity Decreases Atherosclerotic Plaque Formation |
title_sort | impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation |
topic | Brief Rapid Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424975/ https://www.ncbi.nlm.nih.gov/pubmed/25475470 http://dx.doi.org/10.1016/j.cjca.2014.09.019 |
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