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Glycolic Acid-Catalyzed Deamidation of Asparagine Residues in Degrading PLGA Matrices: A Computational Study

Poly(lactic-co-glycolic acid) (PLGA) is a strong candidate for being a drug carrier in drug delivery systems because of its biocompatibility and biodegradability. However, in degrading PLGA matrices, the encapsulated peptide and protein drugs can undergo various degradation reactions, including deam...

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Detalles Bibliográficos
Autores principales: Manabe, Noriyoshi, Kirikoshi, Ryota, Takahashi, Ohgi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425015/
https://www.ncbi.nlm.nih.gov/pubmed/25837471
http://dx.doi.org/10.3390/ijms16047261